CAS No.: 1289023-67-1
(5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate Catalog No. CSN17659
Synonyms: BMS-927711;BHV-3000
BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
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400-920-2911
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03235479 Migraine Acut... more >>e Migraine Phonophobia Photophobia Collapse << Phase 3 Completed - - NCT03461757 Migraine Phase 3 Completed - - NCT03266588 Migraine Phase 2 Phase 3 Active, not recruiting July 2019 - - 更多
- 参考文献
- [1] Zheng N, Zeng J, et al. Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS. J Pharm Biomed Anal. 2014 Feb;89:240-50.
- [2] Luo G, Chen L, et al. Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b] pyridin-9-yl4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-1-yl)piperidine-1-carboxylate(BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine. J Med Chem. 2012 Dec 13;55(23):10644-51.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1289023-67-1 | 储存条件 |
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| 分子式 | C28H28F2N6O3 | 运输 | 蓝冰 | |
| 分子量 | 534.56 | 别名 | BMS-927711;BHV-3000 |
